alaabta

Isticmaalka kiliinikada ee FENO ee Neefta

Fasiraadda Neefta ee MAYA ee neefta

hab ka fudud ayaa lagu soo jeediyay Tilmaamaha Dhaqanka Clinical Society Thoracic ee tarjumaadda FeNO:

• FeNO in ka yar 25 ppb ee dadka waaweyn iyo in ka yar 20 ppb ee carruurta ka yar 12 sano jir waxay tusinaysaa maqnaanshaha caabuqa marin-haweedka eosinophilic.
• FeNO ka weyn 50 ppb dadka waaweyn ama in ka badan 35 ppb ee carruurta waxay soo jeedinaysaa caabuqa marin-haweedka eosinophilic.
• Qiimaha FeNO inta u dhaxaysa 25 iyo 50 ppb ee dadka waaweyn (20 ilaa 35 ppb ee carruurta) waa in si taxadir leh loo fasiraa iyadoo la tixraacayo xaaladda caafimaad.
• FeNO kor u kaca oo leh in ka badan 20 boqolkiiba isbeddel iyo in ka badan 25 ppb (20 ppb ee carruurta) laga soo bilaabo heerkii hore ee xasilloonaa waxay soo jeedinaysaa kororka caabuqa marin-haweedka eosinophilic, laakiin waxaa jira kala duwanaansho ballaaran oo shakhsi ahaaneed.
• Hoos u dhaca FeNO ee ka weyn 20 boqolkiiba qiyamka ka badan 50 ppb ama in ka badan 10 ppb ee qiyamka ka yar 50 ppb ayaa laga yaabaa inay caafimaad ahaan muhiim u tahay.

ogaanshaha iyo sifada neefta

Global Initiative for Neefta waxay ku talinaysaa ka-hortagga isticmaalka FeNO ee ogaanshaha neefta, maadaama laga yaabo inaysan sare u kicin xiiqda noneosinophilic oo laga yaabo inay sare u kacdo cudurrada aan ahayn neefta, sida boronkiitada eosinophilic ama rhinitis xasaasiyadeed.

Sida hagaha daawaynta

Tilmaamaha caalamiga ah waxay soo jeedinayaan isticmaalka heerarka FeNO, marka lagu daro qiimeynta kale (tusaale, daryeelka bukaan-socodka, su'aalaha) si loo hago bilaabista iyo hagaajinta daaweynta xakamaynta neefta.

Isticmaal cilmi-baadhis caafimaad

Nitric oxide oo la sii daayo ayaa door muhiim ah ku leh cilmi-baarista kiliinikada waxayna u badan tahay inay gacan ka geysan doonto ballaarinta fahamka neefta, sida arrimaha ka mas'uulka ah xanuunka neefta iyo goobaha iyo hababka waxqabadka daawooyinka neefta.

U ISTICMAALO XANUUNADA KALE EE NASAASIGA AH

Bronchiectasis iyo cystic fibrosis

Carruurta qaba cystic fibrosis (CF) waxay leeyihiin heerar ka hooseeya FeNO marka loo eego kontaroolada ku habboon.Taas bedelkeeda, hal daraasad ayaa lagu ogaaday in bukaanada qaba non-CF bronchiectasis ay leeyihiin heerar sare oo FeNO ah, iyo heerarkan waxay la xiriiraan heerka aan caadiga ahayn ee ka muuqda laabta CT.

Cudurka sambabada interstitial iyo sarcoidosis

Daraasad lagu sameeyay bukaannada qaba cudurka 'scleroderma', neefta sare ee NO ayaa lagu xusay bukaannada qaba cudurka sambabada interstitial (ILD) marka la barbar dhigo kuwa aan lahayn ILD, halka ka soo horjeeda laga helay daraasad kale.Daraasad lagu sameeyay 52 bukaan oo qaba sarcoidosis, celceliska qiimaha FeNO wuxuu ahaa 6.8 ppb, taas oo aad uga yar barta goynta ee 25 ppb ee loo isticmaalo in lagu muujiyo caabuqa neefta.

Cudurka sambabada ee joogtada ah

FE_NOHeerarka ugu yar ayaa kor loo qaaday COPD deggan, laakiin waxa laga yaabaa inay korodho cudur aad u daran iyo marka ay sii xumaato.Sigaar-cabayaasha hadda waxay leeyihiin qiyaastii 70 boqolkiiba heerarka hoose ee FeNO.Bukaannada qaba COPD, heerarka FeNO ayaa laga yaabaa inay faa'iido u yeeshaan sameynta joogitaanka xannibaadda socodka hawada ee la beddeli karo iyo go'aaminta jawaab-celinta glucocorticoid, inkasta oo aan tan lagu qiimeynin tijaabooyin waaweyn oo la kala soocay.

Neefta kala duwan ee qufaca

FENO waxay leedahay saxnaanta ogaanshaha dhexdhexaadka ah ee saadaasha ogaanshaha cudurka neefta kala duwan ee qufaca (CVA) ee bukaanada qaba qufac raaga.Dib-u-eegis nidaamsan oo lagu sameeyay daraasadaha 13 (bukaanada 2019), qiyaasta goynta ugu fiicnayd ee FENO waxay ahayd 30 ilaa 40 ppb (inkasta oo qiimayaal hoose lagu xusay laba daraasadood), iyo aagga soo koobida ee ka hooseeya qalooca wuxuu ahaa 0.87 (95% CI, 0.83-0.89).Gaar ahaan waxay ahayd mid sare oo joogto ah marka loo eego dareenka.

Eosinophilic boronkiito aan neef lahayn

Bukaannada qaba boronkiitada eosinophilic ee aan neefta lahayn (NAEB), eosinophils xaakada iyo FENO ayaa lagu kordhiyaa tiro la mid ah bukaannada qaba neefta.Dib-u-eegis nidaamsan oo lagu sameeyay afar daraasadood (390 bukaan) bukaannada qaba qufac daba-dheeraaday oo ay sabab u tahay NAEB, heerar goynta FENO ee ugu fiicnaa waxay ahaayeen 22.5 ilaa 31.7 ppb.Dareenka la qiyaasey wuxuu ahaa 0.72 (95% CI 0.62-0.80) waxaana lagu qiyaasay qiyaasta 0.83 (95% CI 0.73-0.90).Markaa, FENO aad ayay uga faa'iido badan tahay in la xaqiijiyo NAEB, halkii laga saari lahaa.

Caabuqyada neef-mareenka sare

Mid ka mid ah daraasadda bukaannada aan lahayn cudurrada sambabada ee hoose, caabuqyada neef-mareenka ee fayrasku waxay keeneen FENO kordhay.

Dhiig-karka sambabada

NO ayaa si fiican loogu aqoonsan yahay dhexdhexaadiyaha pathophysiologic ee hypertension sambabada (PAH).Marka lagu daro vasodilation, MAYA waxay xakameysaa kororka unugyada endothelial iyo angiogenesis, waxayna ilaalisaa caafimaadka xididdada guud.Waxa xiiso leh, bukaannada qaba PAH waxay leeyihiin qiyamka FENO hooseeya.

FENO waxay u muuqataa inay sidoo kale leedahay muhiimad saadaal ah, oo leh badbaado la wanaajiyey ee bukaanada kor u kaca heerka FENO ee daaweynta (calcium channel blockers, epoprostenol, treprostinil) marka la barbardhigo kuwa aan lahayn.Sidaa daraadeed, heerarka hoose ee FENO ee bukaanada qaba PAH iyo hagaajinta daaweynta waxtarka leh waxay soo jeedinayaan inay noqon karto biomarker rajo leh cudurkan.

cilladda ciliary-ga aasaasiga ah

Sanka NO aad ayuu u hooseeyaa ama ka maqan yahay bukaanada qaba cilladda ciliary-ga hoose (PCD).Isticmaalka sanka NO si loogu baadho PCD bukaanada qaba shakiga PCD si gaar ah ayaa looga hadlayaa.

Shuruudo kale

Marka lagu daro dhiig-karka sambabada, xaaladaha kale ee la xidhiidha heerarka hoose ee FENO waxaa ka mid ah hypothermia, iyo bronchopulmonary dysplasia, iyo sidoo kale isticmaalka khamriga, tubaakada, caffeine, iyo daroogooyinka kale.