Waa maxay Nitric Oxide?
Nitric oxide waa gaas ay soo saaraan unugyada ku lug leh bararka la xiriira neefta xasaasiyadda ama eosinophilic.
Waa maxay FeNO?
Baaritaanka neefta ee jajaban ee Nitric Oxide (FeNO) waa hab lagu cabbiro xaddiga nitric oxide ee ku jirta neefta la neefsado. Baaritaankani wuxuu kaa caawin karaa ogaanshaha neefta isagoo muujinaya heerka bararka sambabada.
Faa'iidada Caafimaadka ee FeNO
FeNO waxay bixin kartaa qalab aan duullaan ahayn oo loogu talagalay ogaanshaha bilowga ah ee neefta iyadoo ATS iyo NICE ay ku talinayaan inay qayb ka tahay tilmaamaha hadda jira iyo algorithms-ka ogaanshaha.
| Dadka waaweyn | Carruurta | |
| ATS (2011) | Sare: >50 ppb Dhexdhexaad: 25-50 ppb Hoose: <25 ppb | Sare: >35 ppb Dhexdhexaad: 20-35 ppb Hoose: <20 ppb |
| GINA (2021) | ≥ 20 ppb | |
| NICE (2017) | ≥ 40 ppb | >35 ppb |
| Is-afgaradka Iskotishka (2019) | >40 ppb ICS-bukaanno aan la aqoon >25 bukaan oo ppb ah oo qaadanaya ICS |
Soo gaabin: ATS, American Thoracic Society; FeNO, nitric oxide oo la neefsado oo jajaban; GINA, Global Initiative for Asthma; ICS, corticosteroid neefsan; NICE, Machadka Qaranka ee Caafimaadka iyo Daryeelka Sare.
Tilmaamaha ATS waxay qeexayaan heerarka FeNO ee sare, dhexdhexaadka ah, iyo kuwa hooseeya ee dadka waaweyn inay yihiin >50 ppb, 25 ilaa 50 ppb, iyo <25 ppb, siday u kala horreeyaan. Inta carruurta lagu jiro, heerarka FeNO ee sare, dhexdhexaadka ah, iyo kuwa hooseeya waxaa lagu qeexaa >35 ppb, 20 ilaa 35 ppb, iyo <20 ppb (Jadwalka 1). ATS waxay ku talinaysaa isticmaalka FeNO si loo taageero ogaanshaha neefta halkaas oo loo baahan yahay caddayn ujeedo leh, gaar ahaan ogaanshaha caabuqa eosinophilic. ATS waxay qeexaysaa in heerarka FeNO ee sare (>50 ppb ee dadka waaweyn iyo >35 ppb ee carruurta), marka lagu fasiro macnaha kiliinikada, ay tilmaamayso in bararka eosinophilic uu la socdo jawaab celinta corticosteroid ee bukaanada calaamadaha leh, halka heerarka hoose (<25 ppb ee dadka waaweyn iyo <20 ppb ee carruurta) ay ka dhigayaan mid aan macquul ahayn heerarka dhexdhexaadka ahna waa in si taxaddar leh loo fasiro.
Tilmaamaha NICE ee hadda jira, kuwaas oo isticmaala heerarka FeNO ee ka hooseeya ATS (Jadwalka 1), waxay ku talinayaan in la isticmaalo FeNO qayb ka mid ah shaqada ogaanshaha halka laga fiirsanayo ogaanshaha neefta ee dadka waaweyn ama meesha ay ka jirto hubanti la'aanta ogaanshaha ee carruurta. Heerarka FeNO ayaa mar kale lagu fasiray xaalad caafimaad, baaritaan dheeraad ahna, sida baaritaanka kicinta neefta ayaa laga yaabaa inay gacan ka geystaan cilladda iyadoo la muujinayo jawaab celin xad dhaaf ah oo ku saabsan hawo-mareenka. Tilmaamaha GINA waxay qireen doorka FeNO ee aqoonsashada bararka eosinophilic ee neefta laakiin hadda ma arkaan door FeNO ee algorithms-ka ogaanshaha neefta. Is-afgaradka Scottish wuxuu qeexayaa jarista iyadoo loo eegayo soo-gaadhista steroid iyadoo qiimayaal wanaagsan oo ah >40 ppb bukaanada steroid-ka aan caadiga ahayn iyo >25 ppb bukaanada qaba ICS.
Waqtiga boostada: Maarso-31-2022